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KMID : 0861020120270060029
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Korea Journal of Herbology
2012 Volume.27 No. 6 p.29 ~ p.35
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Antistress effect of Gagamsanzointang on rat chronic stress model
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Kwon Hyuk-Jin
Kim Kyeng-Sub
Kang Su-Kueng
Park Pil-Sang
Lim Ji-Min
Cho Yong-Sik
Choi Yoon-Hee
Park Shin-Young
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Abstract
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Objectives: To observe the effect of 4 kinds of Korean medicine and complex extracts on the anti-stress of chronic mild stress Rat model, so as to find out the machanism of its pharmacological effects.
Methods: 64 healthy SD Rats were randomly divided into 8 groups. Model Design by chronic stress(CSM), and carried out the forced swimming test. We investigated the body weight, feed and water intake, feed conversion ratio and measured parameters to changes in swimming time, immobility time, 2 and 24 hours of feces, corticosterone hormone and blood glucose level.
Results: In this experiments, body weight gain and feed intake were higher in all korean medicinal herb group. Swimming time were increased by Zizyphus jujuba and Gagamsanzointang(SZT) groups and immobility time was significantly lower by Zizyphus jujuba and Fluoxetine(FLX) groups. The result of corticosterone hormone level were significantly lower in Fluoxetine(FLX) and Gagamsanzointang(SZT) but blood glucose was not significantly difference. In 2 hours after fecal frequency result were significantly lower in Zizyphus jujuba group. but SZT group were increased. This result caused by acute stress but 24 hours of feces were restored to normal.
Conclusions: 5 kind of Korean Medicinal Herbs extracts has good anti-stress effects, and also to clear the circulatory system and regulate blood glucose and improve bowel function. We suggest that use a single Korean medicine rather than the combination to relieve stress.
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KEYWORD
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Gagamsanzointang, Zizyphus jujuba, Chronic stress model, Anti-stress, corticosterone
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